Gum Disease (Periodontal disease) and tissue destruction
Gum disease and Tissue Destruction
Denver Dentists Dr. James DeLapp and Dr. H. Candace DeLapp council their patients on the silent destruction that happens with periodontal disease. Periodontal disease (gum disease)causes the following:
- Frequent loss of gum tissue exposing more of your root surface
- Erosion of the bone holding the tooth in the jaw
- Tooth mobility (teeth wiggle back and forth)
- Loss of tooth
- Bad breath
- General fatigue or not feeling well
- Other….
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Tissue Destructive Enzymes
Tissue destructive enzymes has been the focus of researchers for many years in the development of periodontal disease. Essentially what happens is enzymes degrade the collagen (fibrous) network in the gum tissue. Dental researchers Fullmer and Gibson (Nature 1966) revealed that collagenase is present in the gum tissue of the patient. It is this enzyme collagenase that destroys the gum tissue.
Antibiotic use in Periodontal disease
The knowledge on how tissue is destroyed led the Food and Drug Administration to approve the use of a tetracycline class of antibiotic in the treatment of periodontal disease. Doxyxycline is a collagenase-inhibiting antibiotic and helps preserve the architecture and form of the gum tissue. This drug combined with brushing, flossing, diet control and quitting smoking are effective in “most” patients with periodontal disease.
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